Apolipoprotein A-V (APOA5) antibody

Details for Product No. ABIN965569
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Antigen
Synonyms APOA5, MGC140487, rap3, apoav, apoa-v, APOAV, RAP3, apo-AV, apoA-V, 1300007O05Rik, Apoav
Reactivity
Human
(102), (14), (14), (12), (8), (1)
Host
(61), (42), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(81), (80), (12), (10), (9), (7), (4), (1), (1)
Pubmed 2 references available
Quantity 2 x 0.1 mg
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Catalog No. ABIN965569
715.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
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Isotype IgG1
Specificity Ni-NTA purified recombinant human Apoa5 expressed in E. Coli strain BL21 (DE3).
Purification Antibodies are purified by protein G affinity chromatography.
Alternative Name APOA5
Background Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum. This antibody pair detected recombinant apoa5 protein in sandwich ELISA format and could be potential reagents for the development of clinical diagnostic kits.
Gene ID 116519
Application Notes Western Blot: Dilution 1: 1,000- 1: 2,000
Suggested ELISA dilution 1: 4,000
ptimized dilution must be determined by end user.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

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