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AQP2 antibody (Aquaporin 2 (Collecting Duct)) (N-Term)

Details for Product anti-AQP2 Antibody No. ABIN965586, Supplier: Log in to see
Antigen
  • AQP-2
  • AQP-CD
  • aquaporin-2
  • cph
  • jpk
  • WCH-CD
Epitope
N-Term
39
25
20
19
14
14
12
5
5
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
130
123
121
18
13
8
7
4
2
2
1
Host
Rabbit
165
2
Clonality
Polyclonal
Conjugate
This AQP2 antibody is un-conjugated
10
8
5
4
4
4
4
4
4
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
101
59
47
44
35
26
23
7
2
2
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name AQP2 (AQP2 Antibody Abstract)
Background The AQP2(aquaporin 2)is a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. In collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent and phosphorylation of Ser-256 is necessary for expression of AQP2 in the apical membrane. The changes in urinary excretion of aquaporin-2 indicates circulatory blood volume depletion, and estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in patients with diabetic ketoacidosis
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Hirano, Zuber, Roth, Ziak: "The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus." in: The American journal of pathology, Vol. 163, Issue 1, pp. 111-20, 2003

Ogura, Morita, Takeuchi, Otsuka, Iwasaki, Oe, Matsuura, Tobe, Mimura, Kishida, Makino, Hirakawa: "Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia." in: Hormone research, Vol. 59, Issue 1, pp. 30-4, 2003

van Balkom, Savelkoul, Markovich, Hofman, Nielsen, van der Sluijs, Deen: "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41473-9, 2002

Marr, Bichet, Hoefs, Savelkoul, Konings, De Mattia, Graat, Arthus, Lonergan, Fujiwara, Knoers, Landau, Balfe, Oksche, Rosenthal, Müller, Van Os, Deen: "Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus." in: Journal of the American Society of Nephrology : JASN, Vol. 13, Issue 9, pp. 2267-77, 2002

Kusaka, Saito, Nakamura, Nagasaka, Ishibashi, Ishikawa: "Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis." in: Nephron, Vol. 91, Issue 1, pp. 167-9, 2002

Lin, Bichet, Sasaki, Kuwahara, Arthus, Lonergan, Lin: "Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 6, pp. 2694-700, 2002

Marr, Bichet, Lonergan, Arthus, Jeck, Seyberth, Rosenthal, van Os, Oksche, Deen: "Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus." in: Human molecular genetics, Vol. 11, Issue 7, pp. 779-89, 2002