Patatin-Like phospholipase Domain Containing 2 (PNPLA2) (C-Term) antibody

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Antigen
  • zgc:92195
  • PNPLA2
  • pnpla2
  • ATGL
  • 1110001C14Rik
  • PEDF-R
  • TTS-2.2
  • TTS2
  • iPLA2zeta
  • 0610039C21Rik
  • Atgl
  • RGD1309044
  • patatin-like phospholipase domain containing 3
  • patatin-like phospholipase domain containing 2
  • adipose triglyceride lipase
  • pnpla3
  • PNPLA2
  • pnpla2
  • ATGL
  • Pnpla2
Epitope
C-Term
28
22
16
15
15
12
6
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
139
85
35
6
3
2
2
1
1
1
1
Host
Rabbit
93
51
26
5
1
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
6
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
111
79
36
15
13
10
8
4
3
3
1
Options
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATGL(adipose triglyceride lipase)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ATGL (adipose triglyceride lipase) (PNPLA2 Antibody Abstract)
Background ATGL(adipose triglyceride lipase) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. The adipose triglyceride lipase (ATGL) catalyzes the initial step in triglyceride hydrolysis. ATGL contains a patatin domain common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals. The iPLA2epsilon (adiponutrin), iPLA2zeta (TTS2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Schoenborn, Heid, Vollmert, Lingenhel, Adams, Hopkins, Illig, Zimmermann, Zechner, Hunt, Kronenberg: "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes." in: Diabetes, Vol. 55, Issue 5, pp. 1270-5, 2006 (PubMed).

Smirnova, Goldberg, Makarova, Lin, Brown, Jackson: "ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells." in: EMBO reports, Vol. 7, Issue 1, pp. 106-13, 2006 (PubMed).

Zimmermann, Strauss, Haemmerle, Schoiswohl, Birner-Gruenberger, Riederer, Lass, Neuberger, Eisenhaber, Hermetter, Zechner: "Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase." in: Science (New York, N.Y.), Vol. 306, Issue 5700, pp. 1383-6, 2004 (PubMed).

Jenkins, Mancuso, Yan, Sims, Gibson, Gross et al.: "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase ..." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 48968-75, 2004 (PubMed).

Villena, Roy, Sarkadi-Nagy, Kim, Sul: "Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 47066-75, 2004 (PubMed).