C-JUN antibody

Catalog No. ABIN965724

Cited in 4+ publications. The Rabbit Polyclonal anti-C-JUN antibody (ABIN965724) specifically detects C-JUN in IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for C-JUN antibody (ABIN965724)

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C-JUN antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-C-JUN Antibody

Specificity: C-Jun ( Ab-63) antibody detects endogenous levels of c-Jun protein around serine 63.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human c-Jun around the phosphorylation site of serine 63 (L-T-SP-P-D).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-C-JUN antibody (ABIN965724)

Wei, Jin, Schlisio, Harper, Kaelin: "The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase." in: Cancer cell, Vol. 8, Issue 1, pp. 25-33, (2005) (PubMed).

Sevilla, Santos, Barcia, Vega, Lazo: "c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)." in: Oncogene, Vol. 23, Issue 55, pp. 8950-8, (2004) (PubMed).

Li, Feng, Porter: "JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4058-65, (2004) (PubMed).

Hurd, Waldron, Rozengurt: "Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus." in: Oncogene, Vol. 21, Issue 14, pp. 2154-60, (2002) (PubMed).

Target Details for C-JUN

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Alternative Name: c-Jun

Pathways: MAPK Signaling, RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins