Cyclin-Dependent Kinase 9 (CDK9) antibody

Details for Product No. ABIN965846
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Antigen
Synonyms TAK, C-2k, CTK1, CDC2L4, PITALRE, wu:fb22e09, wu:fc06c02, CDK9, CG5179, Dmel\\CG5179, P-TEF, P-TEFb, PTefb, cdk9, c-2k, cdc2l4, ctk1, pitalre, tak
Reactivity
Human
(97), (53), (49), (37), (37), (37), (25), (8), (1), (1)
Host
Mouse
(78), (22)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(72), (51), (30), (24), (23), (13), (4), (4), (2), (2), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN965846
Quantity 0.1 mL
Price
467.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human CDK9 expressed in E. Coli.
Clone 1B5D10
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDK9
Background The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Tissue specificity: Ubiquitous.
Synonyms: TAK, C-2k, CTK1, CDC2L4, PITALRE
Molecular Weight 43kDa
Gene ID 1025
Research Area Cell Cycle
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Storage 4 °C
Product cited in: Montanuy, Torremocha, Hernández-Munain et al.: "Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7368-78, 2008 (PubMed).

Sabò, Lusic, Cereseto et al.: "Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2201-12, 2008 (PubMed).

Hosts (78), (22)
Reactivities (97), (53), (49), (37), (37), (37), (25), (8), (1), (1)
Applications (72), (51), (30), (24), (23), (13), (4), (4), (2), (2), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (18), (16), (8), (7), (2), (1), (1), (1)
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