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CLOCK antibody (Clock Homolog (Mouse)) (N-Term)

Details for Product anti-CLOCK Antibody No. ABIN965906, Supplier: Log in to see
Antigen
  • CG7391
  • CLK
  • CLOCK
  • Dmel\\CG7391
  • Jerk
  • Jrk
  • PAS1
  • bHLHe10
  • clk
  • clock
  • dCLK
  • dCLK/JRK
  • dCLOCK
  • dClck
  • dClk
  • dClock
  • dclk
  • jrk
  • Xclk
  • XClock
  • zCLOCK1
  • zfCLOCK1
  • 5330400M04Rik
  • KAT13D
  • bHLHe8
  • mKIAA0334
  • Clock
  • clock homolog (mouse)
  • clock circadian regulator
  • clock homolog
  • clock
  • circadian locomotor output cycles kaput
  • Clk
  • CLOCK
  • clock
  • Clock
Epitope
N-Term
18
14
5
5
5
4
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
106
52
38
5
4
4
3
3
3
2
2
2
2
1
1
Host
Rabbit
66
37
12
1
Clonality
Polyclonal
Conjugate
This CLOCK antibody is un-conjugated
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
107
46
28
17
10
9
9
4
4
3
2
1
Options
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name CLOCK (CLOCK Antibody Abstract)
Background CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors, Metabolism
Pathways Regulation of Lipid Metabolism by PPARalpha
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Sato, Yamada, Ukai, Baggs, Miraglia, Kobayashi, Welsh, Kay, Ueda, Hogenesch: "Feedback repression is required for mammalian circadian clock function." in: Nature genetics, Vol. 38, Issue 3, pp. 312-9, 2006 (PubMed).

Shirogane, Jin, Ang, Harper: "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26863-72, 2005 (PubMed).

Pirovano, Lorenzi, Serretti, Ploia, Landoni, Catalano, Smeraldi: "Two new rare variants in the circadian "clock" gene may influence sleep pattern." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 7, Issue 6, pp. 455-7, 2005 (PubMed).

Miyazaki, Nagase, Mesaki, Narukawa, Ohara, Ishida: "Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts." in: The Biochemical journal, Vol. 380, Issue Pt 1, pp. 95-103, 2004 (PubMed).

Lee, Weaver, Reppert: "Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 584-94, 2003 (PubMed).

Kondratov, Chernov, Kondratova, Gorbacheva, Gudkov, Antoch: "BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system." in: Genes & development, Vol. 17, Issue 15, pp. 1921-32, 2003 (PubMed).

Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: "Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei." in: Genomics, Vol. 57, Issue 2, pp. 189-200, 1999 (PubMed).

Jin, Shearman, Weaver, Zylka, de Vries, Reppert: "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock." in: Cell, Vol. 96, Issue 1, pp. 57-68, 1999 (PubMed).

Product cited in: Moreira, Pedrazzoli, Dos Santos Coelho, Pradella-Hallinan, Lopes da Conceição, Pereira Peregrino, de Oliveira, Tufik: "Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, 2005 (PubMed).