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DCK antibody (Deoxycytidine Kinase) (N-Term)

Details for Product anti-DCK Antibody No. ABIN965975, Supplier: Log in to see
Antigen
  • dck
  • DCK
  • Dck
  • dck2
  • wu:fe11h12
  • wu:fj05e11
  • zgc:109951
  • wu:fc15f06
  • zgc:101771
  • dck1
Epitope
N-Term
18
14
12
9
8
6
6
4
3
2
2
2
1
Reactivity
Human
98
28
19
2
2
1
1
1
Host
Rabbit
67
33
Clonality
Polyclonal
Conjugate
This DCK antibody is un-conjugated
3
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
86
38
29
29
24
15
11
10
3
3
2
1
1
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DCK (deoxycytidine kinase)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name DCK (DCK Antibody Abstract)
Background Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Research Area Cancer, Cell Cycle
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Innoceta, Galluzzi, Ruzzo et al.: "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells." in: Molecular and cellular biochemistry, Vol. 231, Issue 1-2, pp. 173-7, 2002 (PubMed).

Background publications Krawiec, Kierdaszuk, Shugar: "Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases." in: Biochemical and biophysical research communications, Vol. 301, Issue 1, pp. 192-7, 2003 (PubMed).

Veuger, Heemskerk, Honders et al.: "Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells." in: Blood, Vol. 99, Issue 4, pp. 1373-80, 2002 (PubMed).

Johansson, Brismar, Karlsson: "Human deoxycytidine kinase is located in the cell nucleus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 22, pp. 11941-5, 1997 (PubMed).