DCLRE1C antibody

Catalog No. ABIN965976

This anti-DCLRE1C antibody is a Rabbit Polyclonal antibody detecting DCLRE1C in IHC. Suitable for Human. This Primary Antibody has been cited in 7+ publications.

Quick Overview for DCLRE1C antibody (ABIN965976)

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLRE1C antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DCLRE1C Antibody

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human DCLRE1C (DNA cross-link repair 1C protein)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-DCLRE1C antibody (ABIN965976)

Pannicke, Ma, Hopfner, Niewolik, Lieber, Schwarz: "Functional and biochemical dissection of the structure-specific nuclease ARTEMIS." in: The EMBO journal, Vol. 23, Issue 9, pp. 1987-97, (2004) (PubMed).

Poinsignon, de Chasseval, Soubeyrand, Moshous, Fischer, Haché, de Villartay: "Phosphorylation of Artemis following irradiation-induced DNA damage." in: European journal of immunology, Vol. 34, Issue 11, pp. 3146-55, (2004) (PubMed).

Poinsignon, Moshous, Callebaut, de Chasseval, Villey, de Villartay: "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination." in: The Journal of experimental medicine, Vol. 199, Issue 3, pp. 315-21, (2004) (PubMed).

Ma, Lu, Tippin, Goodman, Shimazaki, Koiwai, Hsieh, Schwarz, Lieber: "A biochemically defined system for mammalian nonhomologous DNA end joining." in: Molecular cell, Vol. 16, Issue 5, pp. 701-13, (2004) (PubMed).

Ma, Pannicke, Schwarz, Lieber: "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination." in: Cell, Vol. 108, Issue 6, pp. 781-94, (2002) (PubMed).

Callebaut, Moshous, Mornon, de Villartay: "Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family." in: Nucleic acids research, Vol. 30, Issue 16, pp. 3592-601, (2002) (PubMed).

Moshous, Callebaut, de Chasseval, Corneo, Cavazzana-Calvo, Le Deist, Tezcan, Sanal, Bertrand, Philippe, Fischer, de Villartay: "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency." in: Cell, Vol. 105, Issue 2, pp. 177-86, (2001) (PubMed).

Target Details for DCLRE1C

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Alternative Name: DCLRE1C

Background: DCLRE1C (DNA cross-link repair 1C protein) is required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Synonyms: ARTEMIS, ASCID, SCIDA, SNM1C

Pathways: DNA Damage Repair