Der1-Like Domain Family, Member 1 (DERL1) (N-Term) antibody

Details for Product No. ABIN965990
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Antigen
Synonyms
CG10908, Dmel\\CG10908, DDBDRAFT_0188135, DDBDRAFT_0266772, DDB_0188135, DDB_0266772, MGC84200, wu:fb09d07, wu:fb94d05, wu:fj92g12, zgc:55637, 1110021N07Rik, AI195141, AW551338, Derlin-1, derlin-1, DE ... show more
CG10908, Dmel\\CG10908, DDBDRAFT_0188135, DDBDRAFT_0266772, DDB_0188135, DDB_0266772, MGC84200, wu:fb09d07, wu:fb94d05, wu:fj92g12, zgc:55637, 1110021N07Rik, AI195141, AW551338, Derlin-1, derlin-1, DER-1, DER1, RGD1311835, DERLIN-1, F17A13.150, F17A13_150 show less
Epitope
N-Term
(24), (8), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(42), (20), (14), (12), (12)
Host
Rabbit
(42), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(31), (17), (16), (10), (7), (3), (2), (2), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN965990
330.00 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name DERL1
Background DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.
Research Area Signaling
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Lilley, Ploegh: "A membrane protein required for dislocation of misfolded proteins from the ER." in: Nature, Vol. 429, Issue 6994, pp. 834-40, 2004 (PubMed).

Ye, Shibata, Yun et al.: "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol." in: Nature, Vol. 429, Issue 6994, pp. 841-7, 2004 (PubMed).

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