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Der1-Like Domain Family, Member 1 (DERL1) (N-Term) antibody

Details for Product No. ABIN965990, Supplier: Log in to see
Antigen
  • CG10908
  • Dmel\\CG10908
  • DDBDRAFT_0188135
  • DDBDRAFT_0266772
  • DDB_0188135
  • DDB_0266772
  • MGC84200
  • wu:fb09d07
  • wu:fb94d05
  • wu:fj92g12
  • zgc:55637
  • 1110021N07Rik
  • AI195141
  • AW551338
  • Derlin-1
  • derlin-1
  • DER-1
  • DER1
  • RGD1311835
  • DERLIN-1
  • F17A13.150
  • F17A13_150
Epitope
N-Term
27
6
3
3
1
1
1
1
Reactivity
Human, Mouse (Murine)
50
21
13
5
Host
Rabbit
47
3
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
35
18
11
11
8
5
2
2
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name DERL1 (DERL1 Antibody Abstract)
Background DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.
Research Area Signaling
Pathways
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Ye, Shibata, Yun et al.: "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol." in: Nature, Vol. 429, Issue 6994, pp. 841-7, 2004 (PubMed).

Lilley, Ploegh: "A membrane protein required for dislocation of misfolded proteins from the ER." in: Nature, Vol. 429, Issue 6994, pp. 834-40, 2004 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).