Der1-Like Domain Family, Member 1 (DERL1) (N-Term) antibody

Antigen: Der1-Like Domain Family, Member 1 (DERL1)

Synonyms: AI195141, AW551338, Derlin-1, 1110021N07Rik, DER1, DER-1, MGC3067, PRO2577, FLJ13784, FLJ42092, RGD1311835, MGC137834, DERL1, DERLIN-1, F17A13.150, F17A13_150, DKFZp468A145, zgc:55637, wu:fb09d07, wu:fb94d05, wu:fj92g12, MGC84200, derl1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965990

Additional Information

Alternative name: DERL1

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)

Description: DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.

Synonyms: AI195141, AW551338, Derlin-1, 1110021N07Rik, DER1, DER-1, MGC3067, PRO2577, FLJ13784, FLJ42092, RGD1311835, MGC137834, DERL1, DERLIN-1, F17A13.150, F17A13_150, DKFZp468A145, zgc:55637, wu:fb09d07, wu:fb94d05, wu:fj92g12, MGC84200, derl1

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Research Area: Signaling

Restrictions: For Research Use only

Publications

Product: Lilley, Ploegh: "A membrane protein required for dislocation of misfolded proteins from the ER." in: Nature, Vol. 429, Issue 6994, pp. 834-40, 2004 (PubMed).

Ye, Shibata, Yun et al.: "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol." in: Nature, Vol. 429, Issue 6994, pp. 841-7, 2004 (PubMed).