DERL1 antibody (C-Term)

Catalog No. ABIN652693

This Rabbit Polyclonal antibody specifically detects DERL1 in WB, IHC (p) and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for DERL1 antibody (C-Term) (ABIN652693)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB22770

Product Details anti-DERL1 Antibody

Binding Specificity: AA 224-251, C-Term

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:16000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: DERL1

Background: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Molecular Weight: 28801

Gene ID: 79139

NCBI Accession: NP_001128143, NP_077271

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling