DERL1 antibody (C-Term)

Catalog No. ABIN453618

The Rabbit Polyclonal anti-DERL1 antibody (ABIN453618) specifically detects DERL1 in WB, IHC (p), FACS and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for DERL1 antibody (C-Term) (ABIN453618)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Product Details anti-DERL1 Antibody

Binding Specificity: AA 222-251, C-Term

Specificity: This antibody recognizes Human and Mouse Derlin-1 at C-term. Other species not tested.

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 222~251 amino acids from the C-term region of Human Derlin-1 Genename: DERL1

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: Derlin-1

Background: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.Synonyms: DER1, DERL1, DERtrin-1, Degradation in endoplasmic reticulum protein 1, Der1-like protein 1

Gene ID: 79139

NCBI Accession: NP_001128143

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling