Epidermal Growth Factor Receptor (EGFR) antibody

Antigen: Epidermal Growth Factor Receptor (EGFR)

Synonyms: ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966041

Additional Information

Alternative name: EGFR

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human EGFR around the phosphorylation site of tyrosine 1092 (P-E-YP-I-N).

Specificity: EGFR (Ab-1092) antibody detects endogenous levels of total EGFR protein.

Synonyms: ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Concentration: 100ug/100ul.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: 0.02% Sodium Azide

Storage: Store at -20°C/1 year.

Restrictions: For Research Use only

Publications

Product: Buerger, Nagel-Wolfrum, Kunz et al.: "Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37610-21, 2003 (PubMed).

Wang, Sun, Paller: "Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites." in: The Journal of biological chemistry, Vol. 278, Issue 49, pp. 48770-8, 2003 (PubMed).

Saito, Okada, Ohshima et al.: "Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF." in: Endocrinology, Vol. 145, Issue 9, pp. 4232-43, 2004 (PubMed).

Pao, Miller, Zakowski et al.: "EGF receptor gene mutations are common in lung cancers from" in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 36, pp. 13306-11, 2004 (PubMed).

Mattila, Pellinen, Nevo et al.: "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP." in: Nature cell biology, Vol. 7, Issue 1, pp. 78-85, 2005 (PubMed).