Glucokinase (Hexokinase 4) (GCK) antibody

Details for Product No. ABIN966192
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Antigen
Synonyms GCK, BA4487, glk, hk4, hhf3, hkiv, hxkp, gck-A, mody2, glucokinase, GLK, Gk, Gls006, HK4, HKIV, HXKP, MODY2, GLUKA, RNGK2, FGQTL3, GK, HHF3, LGLK, AI385662, BL44, Rab8ip
Reactivity
Human
(84), (32), (23), (12), (12), (12), (1)
Host
Mouse
(72), (14)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(71), (46), (31), (15), (11), (10), (6), (3), (3), (2), (2), (2)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN966192
481.25 $
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Immunogen Purified recombinant fragment of human GCK expressed in E. Coli.
Clone 4G6
Isotype IgG1
Purification Ascitic fluid
Alternative Name GCK
Background Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Synonyms: GK, GLK, HK4, HHF3, HKIV, HXKP, LGLK, MODY2, FGQTL3
Molecular Weight 52kDa
Gene ID 2645
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Yoshida, Kato, Yokoi et al.: "Association of genetic variants with chronic kidney disease in individuals with different lipid profiles." in: International journal of molecular medicine, Vol. 24, Issue 2, pp. 233-46, 2009 (PubMed).

Barbetti, Cobo-Vuilleumier, Dionisi-Vici et al.: "Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1983-9, 2009 (PubMed).

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