GRB7 antibody (C-Term)

Catalog No. ABIN966220

Product Details anti-GRB7 Antibody

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRB7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for GRB7

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Alternative Name: GRB7 (Growth factor receptor-bound protein 7) (GRB7 Products)

Background: GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.

Pathways: EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization