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Growth Factor Receptor-Bound Protein 7 (GRB7) (C-Term) antibody

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Antigen
Synonyms mKIAA4028, GRB7
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN966220
Quantity 0.1mg
Price
288.75 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).
Purification Purified by antigen-specific affinity chromatography.

Target Details

Application Details Handling References Alternatives back to top
Alternative Name GRB7 (Growth factor receptor-bound protein 7)
Background GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.

Application Details

Target Details Handling References Alternatives back to top
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Buffer This antibody is stored in PBS, 50% glycerol
Preservative 0.01% Sodium Azide
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Product cited in: Tanaka, Mori, Akiyoshi et al.: "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma." in: Cancer research, Vol. 57, Issue 1, pp. 28-31, 1997 (PubMed).

Kishi, Sasaki, Akiyama et al.: "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer." in: Biochemical and biophysical research communications, Vol. 232, Issue 1, pp. 5-9, 1997 (PubMed).

Tanaka, Mori, Akiyoshi et al.: "A novel variant of human Grb7 is associated with invasive esophageal carcinoma." in: The Journal of clinical investigation, Vol. 102, Issue 4, pp. 821-7, 1998 (PubMed).

Vayssière, Zalcman, Mahé et al.: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Growth Factor Receptor-Bound Protein 7 (GRB7)", type "Antibodies"
Hosts (14), (4), (1)
Reactivities (18), (2)
Applications (16), (9), (1), (1), (1), (1)
Epitopes (6), (1), (1), (1), (1), (1), (1), (1)
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