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Growth Factor Receptor-Bound Protein 7 (GRB7) (C-Term) antibody
|Synonyms||KIAA4028, MGC78181, mKIAA4028, MGC93307, GRB7, MGC138032|
Alternatives Immunohistochemistry (IHC)
|4 references available|
|Price||288.75 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Alternative name||GRB7 (Growth factor receptor-bound protein 7)|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).|
|Description||GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.|
|Application Notes||ELISA, Western blotting: 1µg/ml for 2hrs.|
|Purification||Purified by antigen-specific affinity chromatography.|
|Buffer||This antibody is stored in PBS, 50% glycerol|
|Preservative||0.01% Sodium Azide|
|Storage||Store at -20°C.|
|Restrictions||For Research Use only|
Tanaka, Mori, Akiyoshi et al.: "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma." in: Cancer research, Vol. 57, Issue 1, pp. 28-31, 1997 (PubMed).
Kishi, Sasaki, Akiyama et al.: "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer." in: Biochemical and biophysical research communications, Vol. 232, Issue 1, pp. 5-9, 1997 (PubMed).
Tanaka, Mori, Akiyoshi et al.: "A novel variant of human Grb7 is associated with invasive esophageal carcinoma." in: The Journal of clinical investigation, Vol. 102, Issue 4, pp. 821-7, 1998 (PubMed).
Vayssière, Zalcman, Mahé et al.: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000 (PubMed).
|Hosts||Rabbit (14), Goat (4), Mouse (1)|
|Reactivities||Human (18), Mouse (Murine) (5), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1), Rat (Rattus) (1)|
|Applications||Western Blotting (WB) (16), ELISA (10), Immunohistochemistry (IHC) (2), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||N-Term (5), AA 1-532 (1), C-Term (1), Center (1)|