Growth Factor Receptor-Bound Protein 7 (GRB7) (C-Term) antibody

Details for Product No. ABIN966220
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Antigen
Synonyms GRB7, mKIAA4028
Epitope
C-Term
(8), (6), (6), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(51), (22), (17)
Host
Rabbit
(41), (6), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(40), (21), (10), (7), (5), (4), (4), (3), (2), (2)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN966220
288.75 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).
Purification Purified by antigen-specific affinity chromatography.
Alternative Name GRB7 (Growth factor receptor-bound protein 7)
Background GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Tanaka, Mori, Akiyoshi et al.: "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma." in: Cancer research, Vol. 57, Issue 1, pp. 28-31, 1997 (PubMed).

Kishi, Sasaki, Akiyama et al.: "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer." in: Biochemical and biophysical research communications, Vol. 232, Issue 1, pp. 5-9, 1997 (PubMed).

Tanaka, Mori, Akiyoshi et al.: "A novel variant of human Grb7 is associated with invasive esophageal carcinoma." in: The Journal of clinical investigation, Vol. 102, Issue 4, pp. 821-7, 1998 (PubMed).

Vayssière, Zalcman, Mahé et al.: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000 (PubMed).

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