anti-IFNG antibody (Interferon gamma)

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Antigen
Synonyms IFNG2, IFN-g, Ifg, IFN-G, IFN-gamma, IFNG, IFG, IFI
Alternatives
Reactivity
Human
(685), (310), (162), (59), (38), (26), (22), (21), (14), (14), (13), (12), (9), (9), (9), (9), (7), (6), (6), (6), (6), (6), (5), (3), (2), (1), (1)
Host
(599), (416), (205), (37), (9), (7), (4), (4), (3)
Clonality
Monoclonal
Conjugate
This IFNG antibody is un-conjugated
(173), (124), (71), (46), (40), (14), (13), (12), (10), (8), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(692), (603), (419), (131), (130), (126), (79), (79), (65), (62), (52), (41), (41), (37), (32), (17), (15), (14), (9), (9), (8), (7), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
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Availability Will be delivered in 5 to 7 Business Days
Isotype IgG1
Specificity Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name IFN-Y (IFNG Antibody Abstract)
Background Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
Gene ID 3458
Pathways Interferon-gamma Pathway
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Tsubota, Fukagawa, Fujihara et al.: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, 1999 (PubMed).

Background publications Takayanagi, Ogasawara, Hida et al.: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).

Catalog No. ABIN966336
$385.00
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