Interferon gamma (IFNG) antibody

Details for Product No. ABIN966336
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Antigen
Synonyms IFNG2, IFN-g, Ifg, IFN-G, IFN-gamma, IFNG, IFG, IFI
Reactivity
Human
(614), (308), (152), (60), (32), (21), (21), (20), (17), (14), (13), (12), (11), (10), (10), (9), (7), (6), (6), (6), (6), (6), (5), (3), (2), (1), (1)
Host
(544), (366), (206), (37), (8), (7), (4), (4), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(160), (113), (66), (36), (35), (12), (12), (11), (6), (6), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(647), (547), (409), (113), (111), (106), (78), (75), (58), (44), (41), (36), (30), (25), (19), (8), (7), (7), (7), (6), (6), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Isotype IgG1
Specificity Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name IFN-Y (IFNG Antibody Abstract)
Background Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
Gene ID 3458
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Takayanagi, Ogasawara, Hida et al.: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).

Tsubota, Fukagawa, Fujihara et al.: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, 1999 (PubMed).

Validation Images
Catalog No. ABIN966336
385.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
385.00 $

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