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KSHV ORF62 antibody

Details for Product No. ABIN966466
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Antigen
Reactivity
Kaposi's Sarcoma-associated Herpesvirus (KSHV)
(3), (2), (1)
Host
Please enquire
(6)
Clonality
Monoclonal
Application
Western Blotting (WB), ELISA
(6), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN966466
371.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Isotype IgM
Specificity Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3).
Purification Crude ascites.
Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Chang, Cesarman, Pessin et al.: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, 1995 (PubMed).

Russo, Bohenzky, Chien et al.: "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 25, pp. 14862-7, 1997 (PubMed).

Wu, Lo, Yu et al.: "Three-dimensional structure of the human herpesvirus 8 capsid." in: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, 2000 (PubMed).

Hosts (6)
Reactivities (3), (2), (1)
Applications (6), (4), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN966466
371.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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