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Details for Product No. ABIN966466

KSHV ORF62 antibody

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Antigen
Reactivity
»Alternatives Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Host
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 3 references available
Catalog no. ABIN966466
Quantity 0.1 mg
Price
371.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Isotype IgM
Specificity Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3).
Purification Crude ascites.
Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Product cited in: Chang, Cesarman, Pessin et al.: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, 1995 (PubMed).

Russo, Bohenzky, Chien et al.: "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 25, pp. 14862-7, 1997 (PubMed).

Wu, Lo, Yu et al.: "Three-dimensional structure of the human herpesvirus 8 capsid." in: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, 2000 (PubMed).

Alternatives for antigen "KSHV ORF62", type "Antibodies"
Hosts (6)
Reactivities (3), (1), (1)
Applications (6), (5), (3), (2), (1)
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