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L3MBTL1 antibody (L(3)mbt-Like 1 (Drosophila)) (N-Term)

Details for Product anti-L3MBTL1 Antibody No. ABIN966472, Supplier: Log in to see
Antigen
  • C630004G01
  • dJ138B7.3
  • H-L(3)MBT
  • L3mbtl
  • L3MBTL
  • mKIAA0681
  • RGD1307316
  • ZC2HC3
Epitope
N-Term
8
3
2
2
2
1
1
1
1
1
Reactivity
Human
30
5
2
1
1
Host
Rabbit
30
3
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
30
12
6
5
3
2
1
Supplier
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Supplier Product No.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )
Alternative Name L3MBTL (L3MBTL1 Antibody Abstract)
Background L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
Synonyms: KIAA0681, L3MBT, L3MBTL1
Restrictions For Research Use only
Background publications Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).

Ishikawa, Nagase, Suyama, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 3, pp. 169-76, 1998 (PubMed).

Product cited in: Boccuni, MacGrogan, Scandura, Nimer: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, 2003 (PubMed).

Wang, Tereshko, Boccuni, MacGrogan, Nimer, Patel: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." in: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, 2003 (PubMed).

Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." in: Oncogene, Vol. 18, Issue 26, pp. 3799-809, 1999 (PubMed).