L(3)mbt-Like 1 (Drosophila) (L3MBTL1) (N-Term) antibody

Antigen: L(3)mbt-Like 1 (Drosophila) (L3MBTL1)

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966472

Additional Information

Alternative name: L3MBTL

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )

Description: L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
Synonyms: KIAA0681, L3MBT, L3MBTL1

Application Details

Restrictions: For Research Use only

Publications

Product: Ishikawa, Nagase, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 3, pp. 169-76, 1998 (PubMed).

Koga, Matsui, Hirota et al.: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." in: Oncogene, Vol. 18, Issue 26, pp. 3799-809, 1999 (PubMed).

Boccuni, MacGrogan, Scandura et al.: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, 2003 (PubMed).

Wang, Tereshko, Boccuni et al.: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." in: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, 2003 (PubMed).

Bechtel, Rosenfelder, Duda et al.: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).