serine/threonine Kinase 11 (STK11) (C-Term,AA 421-433) antibody

Antigen: serine/threonine Kinase 11 (STK11)

Synonyms: xeek1, Stk11, STK11, pjs, LKB1, XEEK1, wu:fj61a05, zgc:110180

Binding Site: C-Term,AA 421-433

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN966488

Additional Information

Alternative name: LKB1

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human STK11 (421-433 aa), different from the mouse sequence by one amino acid.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al. (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al. (2001) demonstrated that LKB1 physically associates with p53 (191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al. (1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al. (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Cancer, Cell Cycle

Restrictions: For Research Use only

Publications

Product: Jenne, Reimann, Nezu et al.: "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase." in: Nature genetics, Vol. 18, Issue 1, pp. 38-43, 1998 (PubMed).