Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody

Details for Product No. ABIN966514
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Antigen
Synonyms
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek ... show more
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek1, 2, JNKK, Jnkk2, Mapkk7, Mek7, Mkk7, JNKK1, MEK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Serk1, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, F19C24.26, F19C24_26, MAP KINASE KINASE 4, mitogen-activated protein kinase kinase 4, MKK4A-l, map2k4, zgc:136500 show less
Reactivity
Human
(275), (163), (153), (60), (52), (48), (36), (12), (2), (2), (1)
Host
(248), (30), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(168), (111), (85), (55), (50), (44), (17), (15), (8), (7), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN966514
385.00 $
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Isotype IgM
Specificity Ni-NTA purified truncated recombinant MAP2K4 expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name MAP2K4
Background MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases. MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
Gene ID 6416
Application Notes Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Crews, Alessandrini, Erikson: "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 478-80, 1992 (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, 2000 (PubMed).

Kim, Vander Griend, Yang et al.: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, 2001 (PubMed).

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