Mitogen-Activated Protein Kinase 7 (MAPK7) (Isoform 1,C-Term) antibody

Antigen: Mitogen-Activated Protein Kinase 7 (MAPK7)

Synonyms: BMK1, ERK4, ERK5, PRKM7, Erk5-T, ATMPK7, F8D23.5, F8D23_5, MAP kinase 7, MPK7

Binding Site: Isoform 1,C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966527

Additional Information

Alternative name: MAPK7

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human MAPK7 (mitogen-activated protein kinase 7 isoform 1)

Description: MAPK7 (mitogen-activated protein kinase 7 isoform 1) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Synonyms: BMK1, ERK4, ERK5, PRKM7

Application Details

Restrictions: For Research Use only

Publications

Product: English, Pearson, Baer et al.: "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 3854-60, 1998 (PubMed).

Kato, Tapping, Huang et al.: "Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor." in: Nature, Vol. 395, Issue 6703, pp. 713-6, 1998 (PubMed).

Purandare, Lee, Patel: "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids." in: Cytogenetics and cell genetics, Vol. 83, Issue 3-4, pp. 258-9, 1999 (PubMed).

Esparís-Ogando, Díaz-Rodríguez, Montero et al.: "Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2." in: Molecular and cellular biology, Vol. 22, Issue 1, pp. 270-85, 2001 (PubMed).

Buschbeck, Eickhoff, Sommer et al.: "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 29503-9, 2002 (PubMed).

Arnoux, Nassour, LHelgoualch et al.: "Erk5 controls Slug expression and keratinocyte activation during wound healing." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4738-49, 2008 (PubMed).

Zen, Yasui, Nakajima et al.: "ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry." in: Genes, chromosomes & cancer, Vol. 48, Issue 2, pp. 109-20, 2008 (PubMed).

Zhao, Geng, Ge et al.: "Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells." in: Molecular and cellular biochemistry, Vol. 322, Issue 1-2, pp. 171-8, 2009 (PubMed).

Sawhney, Liu, Brattain: "A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling." in: Journal of cellular physiology, Vol. 219, Issue 1, pp. 152-61, 2009 (PubMed).

Montero, Ocaña, Abad et al.: "Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target." in: PLoS ONE, Vol. 4, Issue 5, pp. e5565, 2009 (PubMed).