PRTN3 antibody

Catalog No. ABIN966909

Product Details anti-PRTN3 Antibody

Target: PRTN3 (Proteinase 3 (PRTN3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRTN3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibodies are purified by protein G affinity chromatography.

Immunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Clone: 3B4

Isotype: IgG2b

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-PRTN3 antibody (ABIN966909)

Clin, Aubin, Parent, Ronsky, Labelle: "Biomechanical modeling of brace design." in: Studies in health technology and informatics, Vol. 123, pp. 255-60, (2006) (PubMed).

Abdgawad, Hellmark, Gunnarsson, Westman, Segelmark: "Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism." in: Clinical and experimental immunology, Vol. 145, Issue 1, pp. 63-70, (2006) (PubMed).

Target Details for PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Alternative Name: Proteinase 3 (PRTN3 Products)

Synonyms: ela2 antibody, MGC132250 antibody, ACPA antibody, AGP7 antibody, C-ANCA antibody, CANCA antibody, MBN antibody, MBT antibody, NP-4 antibody, NP4 antibody, P29 antibody, PR-3 antibody, PR3 antibody, mPR3 antibody, proteinase 3 L homeolog antibody, proteinase 3 antibody, prtn3.L antibody, PRTN3 antibody, Prtn3 antibody

Background: Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Synonyms: PRTN3, ACPA, CANCA

Molecular Weight: 28kDa

Gene ID: 5657