Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (N-Term) antibody

Antigen: Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B)

Synonyms: p53R2, MGC42116, MGC102856, DKFZp686M05248, p53r2, MGC52676, RRM2B, DKFZp469M156

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966974

Additional Information

Alternative name: RRM2B

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)

Description: RRM2B (Ribonucleoside-diphosphate reductase subunit M2B) plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. RRM2B supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. RRM2B contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. RRM2B binds 2 iron ions per subunit. RRM2B interacts with p53/TP53 and interacts with RRM1 in response to DNA damage. RRM2B is widely expressed at a high level in skeletal muscle and at a weak level in thymus. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT)
Synonyms: P53R2( p53-inducible ribonucleotide reductase small subunit 2-like protein)

Application Details

Restrictions: For Research Use only

Publications

Product: Tanaka, Arakawa, Yamaguchi et al.: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." in: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000 (PubMed).

Guittet, Håkansson, Voevodskaya et al.: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, 2001 (PubMed).

Yamaguchi, Matsuda, Sagiya et al.: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, 2001 (PubMed).

Xue, Zhou, Liu et al.: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, 2003 (PubMed).

Bechtel, Rosenfelder, Duda et al.: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).