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SET Domain, Bifurcated 1 (SETDB1) antibody

Details for Product No. ABIN967016, Supplier: Log in to see
Antigen
  • SETDB1
  • NV10069
  • fc07d03
  • si:ch211-81a5.6
  • wu:fc07d03
  • ESET
  • H3-K9-HMTase4
  • KG1T
  • KMT1E
  • TDRD21
  • AU022152
  • mKIAA0067
Reactivity
Human, Monkey, Mouse (Murine)
89
33
20
9
Host
Mouse
66
23
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
74
44
20
11
9
7
6
5
3
1
1
Supplier
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Immunogen Purified recombinant fragment of human SETDB1 expressed in E. Coli.
Clone 5H6D4
Isotype IgG1
Purification Ascitic fluid
Alternative Name SETDB1 (SETDB1 Antibody Abstract)
Background This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-Lmethionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression.
Tissue specificity: Widely expressed. High expression in testis.
Synonyms: ESET, KG1T, KMT1E, KIAA0067, H3-K9-HMTase4, SETDB1
Molecular Weight 180kDa
Gene ID 9869
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Gao, Yu, Bi et al.: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, 2007 (PubMed).

Background publications Rosendorff, Sakakibara, Lu et al.: "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5308-13, 2006 (PubMed).

Gevaert, Staes, Van Damme et al.: "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC." in: Proteomics, Vol. 5, Issue 14, pp. 3589-99, 2005 (PubMed).