Snail Homolog 2 (Drosophila) (SNAI2) (C-Term) antibody

Details for Product No. ABIN967057
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Antigen
Synonyms slug, ws2d, xSlu, xslug, Snail2, slugh1, XSnail2, snai2, SLUG, SLUGH1, SNAIL2, WS2D, Slug, xsna, Slugh, cb147, cb355, id:ibd5003, sb:cb355, sb:cb569, wu:fb83e12, wu:fd19g11, zgc:92564
Epitope
C-Term
(13), (13), (13), (13), (13), (9), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(108), (52), (39), (13), (13), (13), (13), (1)
Host
Rabbit
(67), (41)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Immunohistochemistry (IHC)
(81), (37), (20), (20), (16), (13), (7), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN967057
466.13 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near C-terminal residues of human SNAI2
Alternative Name SNAI2
Background SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D
Restrictions For Research Use only
Product cited in: Inukai, Inoue, Kurosawa et al.: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, 1999 (PubMed).

Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).

Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Wang, Wang, Chang et al.: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, 2009 (PubMed).

Larriba, Martín-Villar, García et al.: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, 2009 (PubMed).

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