Snail Homolog 2 (Drosophila) (SNAI2) (C-Term) antibody

Antigen: Snail Homolog 2 (Drosophila) (SNAI2)

Synonyms: SLUG, WS2D, SLUGH1, MGC10182, Slug, Slugh, Snail2, SNAI2, slug, cb147, cb355, sb:cb355, sb:cb569, zgc:92564, id:ibd5003, wu:fb83e12, wu:fd19g11, MGC127347, snai2-a, xsna, MGC64246, ws2d, xSlu, xslug, slugh1, XSnail2

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN967058

Additional Information

Alternative name: SNAI2

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human SNAI2

Description: SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D

Synonyms: SLUG, WS2D, SLUGH1, MGC10182, Slug, Slugh, Snail2, SNAI2, slug, cb147, cb355, sb:cb355, sb:cb569, zgc:92564, id:ibd5003, wu:fb83e12, wu:fd19g11, MGC127347, snai2-a, xsna, MGC64246, ws2d, xSlu, xslug, slugh1, XSnail2

Application Details

Restrictions: For Research Use only

Publications

Product: Inukai, Inoue, Kurosawa et al.: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, 1999 (PubMed).

Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).

Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Wang, Wang, Chang et al.: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, 2009 (PubMed).

Larriba, Martín-Villar, García et al.: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, 2009 (PubMed).