Add to Basket
|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Snail Homolog 2 (Drosophila) (SNAI2) (C-Term) antibody
Human, Mouse (Murine), Rat (Rattus)
Alternatives Immunohistochemistry (IHC)
|5 references available|
|Price||452.38 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human SNAI2|
SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D
|Synonyms||SLUG, WS2D, SLUGH1, MGC10182, Slug, Slugh, Snail2, SNAI2, slug, cb147, cb355, sb:cb355, sb:cb569, zgc:92564, id:ibd5003, wu:fb83e12, wu:fd19g11, MGC127347, snai2-a, xsna, MGC64246, ws2d, xSlu, xslug, slugh1, XSnail2|
|Restrictions||For Research Use only|
Inukai, Inoue, Kurosawa et al.: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, 1999 (PubMed).
Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).
Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).
Wang, Wang, Chang et al.: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, 2009 (PubMed).
Larriba, Martín-Villar, García et al.: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, 2009 (PubMed).
|Hosts||Rabbit (47), Mouse (14)|
|Reactivities||Human (61), Mouse (Murine) (31), Rat (Rattus) (29), Chicken (19), Cow (Bovine) (19), Dog (Canine) (19), Pig (Porcine) (19), Xenopus laevis (1)|
|Applications||Western Blotting (WB) (36), ELISA (30), Immunofluorescence (IF) (26), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Fluorescence Microscopy (FM) (1), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)|
|Epitopes||Internal Region (6), pTyr164,pTyr169,pSer160,pSer158,pSer155 (4), Center (3), N-Term (2), AA 82-100 (1), AA 97-169 (1), C-Term (1), C-Term,pSer155,pSer158,pSer160,pTyr164,pTyr169 (1), pSer338 (1)|