Suppressor of Cytokine Signaling 2 (SOCS2) (C-Term,AA 181-198) antibody

Antigen: Suppressor of Cytokine Signaling 2 (SOCS2)

Synonyms: CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Socs-2, SOCS2, si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2

Binding Site: C-Term,AA 181-198

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN967065

Additional Information

Alternative name: SOCS2

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Signaling, Innate Immunity, Cytokines

Restrictions: For Research Use only

Publications

Product: Minamoto, Ikegame, Ueno et al.: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, 1997 (PubMed).

Masuhara, Sakamoto, Matsumoto et al.: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, 1997 (PubMed).

Dey, Spence, Nissley et al.: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, 1998 (PubMed).

Greenhalgh, Bertolino, Asa et al.: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, 2002 (PubMed).