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Suppressor of Cytokine Signaling 2 (SOCS2) (C-Term,AA 181-198) antibody
|Synonyms||CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Socs-2, SOCS2, si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2|
Human, Rat (Rattus)
Alternatives Western Blotting (WB)
|4 references available|
|Price||316.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.|
|Reconstitution||0.2ml of distilled water will yield a concentration of 500µg/ml.|
|Description||Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.|
|Buffer||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4|
|Preservative||0.05mg Thiomersal, 0.05mg NaN3.|
|Storage||At -20°C for one year. After reconstitution, at 4°C for one month.|
|Research Area||Signaling, Innate Immunity, Cytokines|
|Restrictions||For Research Use only|
Minamoto, Ikegame, Ueno et al.: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, 1997 (PubMed).
Masuhara, Sakamoto, Matsumoto et al.: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, 1997 (PubMed).
Dey, Spence, Nissley et al.: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, 1998 (PubMed).
Greenhalgh, Bertolino, Asa et al.: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, 2002 (PubMed).
|Hosts||Rabbit (26), Goat (3)|
|Reactivities||Human (29), Cow (Bovine) (18), Dog (Canine) (18), Horse (Equine) (18), Mouse (Murine) (18), Pig (Porcine) (18), Rat (Rattus) (18)|
|Applications||Immunofluorescence (IF) (15), Western Blotting (WB) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), ELISA (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|