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Contactin Associated Protein 1 (CNTNAP1) (AA 1-1513) antibody

Details for Product No. ABIN967781, Supplier: Log in to see
Antigen
  • CNTNAP1
  • CASPR
  • CNTNAP
  • NRXN4
  • P190
  • Caspr
  • AI841080
  • NCP1
  • Nrxn4
  • p190
  • shm
Epitope
AA 1-1513
13
6
3
2
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
33
22
21
2
1
1
1
Host
Mouse
26
9
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
22
11
8
8
5
5
2
2
2
1
Supplier
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Immunogen Human p190 aa. 1-1513
Clone 30-p190
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken, Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p190 (CNTNAP1 Antibody Abstract)
Background GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.
Molecular Weight 190 kDa
Pathways
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Contactin Associated Protein 1 (CNTNAP1) (AA 1-1513) antibody (ABIN967781) Western blot analysis of p190 on HeLa lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: ...
 image for anti-Contactin Associated Protein 1 (CNTNAP1) (AA 1-1513) antibody (ABIN967781) Human Fibroblast
 image for anti-Contactin Associated Protein 1 (CNTNAP1) (AA 1-1513) antibody (ABIN967781) anti-Contactin Associated Protein 1 (CNTNAP1) (AA 1-1513) antibody (Image 3)
Product cited in: Wolf, Draghi, Liang et al.: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." in: Genes & development, Vol. 17, Issue 4, pp. 476-87, 2003 (PubMed).

Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, 2003 (PubMed).

Brandt, Gimona, Hillmann et al.: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." in: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, 2002 (PubMed).

Nakahara, Mueller, Nomizu et al.: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, 1998 (PubMed).

Settleman, Narasimhan, Foster et al.: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." in: Cell, Vol. 69, Issue 3, pp. 539-49, 1992 (PubMed).