A Kinase (PRKA) Anchor Protein 5 (AKAP5) (AA 180-427) antibody

Details for Product No. ABIN967900
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Synonyms AKAP5, AKAP75, AKAP79, H21, AKAP, P75, 3526401B18Rik, AKAP 150, AKAP-5, AKAP150, BB098886, Gm258, P150, Akap79
AA 180-427
(15), (15), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
(61), (17), (15), (2), (2), (1), (1)
(59), (5)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(52), (33), (12), (11), (10), (3), (3), (3), (1)
Pubmed 4 references available
Quantity 50 μg
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Immunogen Human AKAP79 aa. 180-427
Clone 22-AKAP79
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name AKAP79 (AKAP5 Antibody Abstract)
Background The type II cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain this localization of type II PKAs, the regulatory subunit (RII) interacts with specific RII-anchoring proteins. For instance, attachment of type II PKA to the cytoskeleton occurs through the binding of RII to microtubule-associated protein 2 (MAP2). In brain, several proteins have been identified as PKA type II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP79 is a 79kDa human RII-anchoring protein. AKAP, PKA type II, and calcineurin (PP2B) can form a tertiary complex, suggesting that both PKA and calcineurin are targeted by a common protein to subcellular sites where they regulate the phosphorylation status of key substrates.
Molecular Weight 79 kDa

Related Products: ABIN968552, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-A Kinase (PRKA) Anchor Protein 5 (AKAP5) (AA 180-427) antibody (ABIN967900) Western blot analysis of AKAP79 on SW13 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3:...
Immunofluorescence (IF) image for anti-A Kinase (PRKA) Anchor Protein 5 (AKAP5) (AA 180-427) antibody (ABIN967900) Immunofluorescent staining of endothelial cells.
Image no. 3 for anti-A Kinase (PRKA) Anchor Protein 5 (AKAP5) (AA 180-427) antibody (ABIN967900) anti-A Kinase (PRKA) Anchor Protein 5 (AKAP5) (AA 180-427) antibody (Image 3)
Product cited in: Schillace, Andrews, Liberty et al.: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, 2002 (PubMed).

Jicha, Weaver, Lane et al.: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, 1999 (PubMed).

Coghlan, Perrino, Howard et al.: "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein." in: Science (New York, N.Y.), Vol. 267, Issue 5194, pp. 108-11, 1995 (PubMed).

Carr, Stofko-Hahn, Fraser et al.: "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79." in: The Journal of biological chemistry, Vol. 267, Issue 24, pp. 16816-23, 1992 (PubMed).

Validation Images
Catalog No. ABIN967900
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