Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

NOS2 antibody (AA 961-1144)

NOS2 Reactivity: Mouse WB, IHC, IP, IF Host: Mouse Monoclonal 6-iNOS-NOS Type II unconjugated
Catalog No. ABIN967905
  • Target See all NOS2 Antibodies
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Binding Specificity
    • 16
    • 16
    • 12
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 961-1144
    Reactivity
    • 110
    • 69
    • 69
    • 17
    • 2
    • 1
    Mouse
    Host
    • 127
    • 10
    Mouse
    Clonality
    • 119
    • 18
    Monoclonal
    Conjugate
    • 69
    • 16
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This NOS2 antibody is un-conjugated
    Application
    • 110
    • 45
    • 34
    • 32
    • 27
    • 26
    • 23
    • 18
    • 17
    • 14
    • 8
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse iNOS aa. 961-1144
    Clone
    6-iNOS-NOS Type II
    Isotype
    IgG2a
    Top Product
    Discover our top product NOS2 Primary Antibody
  • Comment

    Related Products: ABIN968550, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Heneka, Klockgether, Feinstein: "Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 18, pp. 6862-7, (2000) (PubMed).

    Marrogi, Pass, Khan, Metheny-Barlow, Harris, Gerwin: "Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor." in: Cancer research, Vol. 60, Issue 14, pp. 3696-700, (2000) (PubMed).

    Miles, Bowman, Rao, Baatz, Huffman: "Pulmonary surfactant inhibits LPS-induced nitric oxide production by alveolar macrophages." in: The American journal of physiology, Vol. 276, Issue 1 Pt 1, pp. L186-96, (1999) (PubMed).

    Sciorati, Rovere, Ferrarini, Heltai, Manfredi, Clementi: "Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 37, pp. 23211-5, (1997) (PubMed).

    Xie, Cho, Calaycay, Mumford, Swiderek, Lee, Ding, Troso, Nathan: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." in: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).

  • Target
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Alternative Name
    iNOS/NOS Type II (NOS2 Products)
    Synonyms
    HEP-NOS antibody, INOS antibody, NOS antibody, NOS2A antibody, NOS-II antibody, Nos-2 antibody, Nos2a antibody, i-NOS antibody, iNOS antibody, iNos antibody, NOS2a antibody, NOS2 antibody, BmNOS2 antibody, Nsl antibody, nos2 antibody, nitric oxide synthase 2 antibody, nitric oxide synthase 2, inducible antibody, inducible nitric oxide synthase antibody, inducible nitric-oxide synthase antibody, nanos C2HC-type zinc finger 2 antibody, NOS2 antibody, Nos2 antibody, nos2 antibody, LOC396821 antibody, NANOS2 antibody
    Background
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-gamma, TNF-alpha, and IL-1) and microbial products (lipopolysaccharide (LPS)), iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFkappaB. Data indicates that TGF-beta affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain.
    Molecular Weight
    130 kDa
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
You are here:
Support