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Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 225-401) antibody

Details for Product No. ABIN968323
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Antigen
Synonyms xCaspase-2, Caspase-2, ICH-1, Nedd2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, ICH-1L/1S, ICH1L1S
Epitope
AA 225-401
(19), (12), (11), (8), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(132), (48), (34), (12), (12), (8), (5), (1)
Host
Mouse
(109), (32), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(119), (65), (25), (22), (14), (13), (10), (7), (7), (6), (1)
Pubmed 5 references available
Quantity 50 µg
Options
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Catalog No. ABIN968323
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Immunogen Human ICH-1L
Clone G52C7-1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Caspase-2
Background Caspase-2/ICH-1 is related to the C. elegans cell death gene product CED-3 and its mammalian homologue interleukin-1beta-converting enzyme (ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice and ced-3 homology. Caspase-2/ICH-1 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis, while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an important dual role in programmed cell death.
Synonyms: ICH-1L
Molecular Weight 48 kDa
Research Area Apoptosis/Necrosis, Cancer, Autophagy
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 225-401) antibody Western blot analysis of Caspase-2 on Jurkat cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-Caspase-2.
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 225-401) antibody (2) Immunofluorescent staining of FHS cells.
Product cited in: Wang, Miura, Bergeron et al.: "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death." in: Cell, Vol. 78, Issue 5, pp. 739-50, 1994 (PubMed).

Mancini, Machamer, Roy et al.: "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis." in: The Journal of cell biology, Vol. 149, Issue 3, pp. 603-12, 2000 (PubMed).

Shibata, Hisahara, Hara et al.: "Caspases determine the vulnerability of oligodendrocytes in the ischemic brain." in: The Journal of clinical investigation, Vol. 106, Issue 5, pp. 643-53, 2000 (PubMed).

Guo, Srinivasula, Druilhe et al.: "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13430-7, 2002 (PubMed).

Li, Chen, Sinogeeva et al.: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, 2002 (PubMed).

Validation Images
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