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Aurora Kinase B antibody (AA 2-124)

AURKB Reactivity: Human, Mouse, Rat WB, IF Host: Mouse Monoclonal 6-AIM unconjugated
Catalog No. ABIN968357
  • Target See all Aurora Kinase B (AURKB) Antibodies
    Aurora Kinase B (AURKB)
    Binding Specificity
    • 21
    • 20
    • 18
    • 13
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-124
    Reactivity
    • 134
    • 68
    • 35
    • 12
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 130
    • 23
    • 3
    • 1
    Mouse
    Clonality
    • 116
    • 42
    Monoclonal
    Conjugate
    • 82
    • 13
    • 10
    • 9
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Aurora Kinase B antibody is un-conjugated
    Application
    • 102
    • 73
    • 50
    • 34
    • 20
    • 14
    • 14
    • 13
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat AIM-1 aa. 2-124
    Clone
    6-AIM
    Isotype
    IgG1
    Top Product
    Discover our top product AURKB Primary Antibody
  • Comment

    Related Products: ABIN967389, ABIN968537

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Trinkle-Mulcahy, Andrews, Wickramasinghe, Sleeman, Prescott, Lam, Lyon, Swedlow, Lamond: "Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 107-17, (2003) (PubMed).

    Chen, Jin, Tahir, Zhang, Liu, Sarthy, McGonigal, Liu, Rosenberg, Ng: "Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 486-90, (2002) (PubMed).

    Lange, Rebollo, Herold, González: "Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes." in: The EMBO journal, Vol. 21, Issue 20, pp. 5364-74, (2002) (PubMed).

    Tatsuka, Katayama, Ota, Tanaka, Odashima, Suzuki, Terada: "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells." in: Cancer research, Vol. 58, Issue 21, pp. 4811-6, (1998) (PubMed).

    Terada, Tatsuka, Suzuki, Yasuda, Fujita, Otsu: "AIM-1: a mammalian midbody-associated protein required for cytokinesis." in: The EMBO journal, Vol. 17, Issue 3, pp. 667-76, (1998) (PubMed).

  • Target
    Aurora Kinase B (AURKB)
    Alternative Name
    AIM-1 (AURKB Products)
    Synonyms
    AIK2 antibody, AIM-1 antibody, AIM1 antibody, ARK2 antibody, AurB antibody, IPL1 antibody, PPP1R48 antibody, STK12 antibody, STK5 antibody, aurkb-sv1 antibody, aurkb-sv2 antibody, AIRK2 antibody, AL022959 antibody, Aik2 antibody, Aim1 antibody, Ark2 antibody, STK-1 antibody, Stk12 antibody, Stk5 antibody, Aur B antibody, Aurora B antibody, Aurora-B antibody, CG6620 antibody, DmAIRK2 antibody, DmAurB antibody, DmAuroraB antibody, Dmel\\CG6620 antibody, IAL antibody, IAL1 antibody, Ial antibody, aurB antibody, aurora B antibody, ARK-2 antibody, XAIRK2 antibody, aik2 antibody, aim-1 antibody, aim1 antibody, airk2 antibody, ark2 antibody, ipl1 antibody, stk12 antibody, stk5 antibody, CHUNP6896 antibody, fa09g06 antibody, stka antibody, wu:fa09g06 antibody, aurkb antibody, AIRK2-B antibody, XAIRK2-B antibody, aurkb-a antibody, aurkb-b antibody, xAurora-B-B antibody, aurora kinase B antibody, aurora B antibody, aurora kinase B S homeolog antibody, AURKB antibody, Aurkb antibody, aurB antibody, aurkb antibody, aurkb.S antibody
    Background
    The mitotic phase of the cell cycle is a complex process that ensures the fidelity of chromosome segregation. During the final stage of mitosis (telophase), segregated chromosomes become less condense and nuclear membranes surround the two sets of daughter chromosomes. Simultaneously, the separation and segregation of the cytoplasm (cytokinesis) ensures complete division and formation of two identical daughter cells. Regulation of cytokinesis is poorly understood and errors in this process can lead to cell death or oncogenesis. The Drosophila serine/threonine protein kinase Aurora and the S. cerevisiae Ipl1 kinase are highly homologous and are required for progression through mitosis. Their mammalian homolog AIM-1 (also known as Aurora and Ipl1-like midbody associated protein) accumulates at the G2/M interface. During late anaphase, AIM-1 is found at the equator of central spindles. However, during telophase and cytokinesis, it is found at the midbody. Although over-expression of a kinase-inactive AIM-1 mutant disrupts formation of the cleavage furrow, nuclear division is unaffected. Thus, it is thought that AIM-1 is essential for cleavage furrowing and the onset of cytokinesis.
    Synonyms: Aurora B, Aurora and Ipl1-like midbody associated protein
    Molecular Weight
    41 kDa
    Pathways
    TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
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