Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2) (AA 85-194) antibody

Details for Product No. ABIN968579
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Antigen
Synonyms GT24, NPRAP, Nprap, Catnd2, neurojugin, CTNND2
Epitope
AA 85-194
(4), (3), (2), (1), (1), (1)
Reactivity
Mouse (Murine)
(13), (6), (5), (4), (1)
Host
Mouse
(8), (6), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(16), (5), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN968579
Quantity 50 µg
Price
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Immunogen Mouse delta-Catenin
Clone OPG-13
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name delta-Catenin
Background The catenins (alpha, beta, gamma, delta, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1 homolog) signaling pathway. alpha-Catenin has two subtypes: alphaE-Catenin, which is expressed ubiquitously, and alphaN-Catenin, which is expressed in the nervous system. beta-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling. gamma-Catenin is associated with desmoglein in desmosomes and is closely related to beta-Catenin. p120[ctn] is related to both beta- and gamma-catenin and is a substrate of tyrosine kinases localized at adherens junctions. delta-catenin was identified by its ability to bind the Alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as compared to the 13 Arm repeats found in beta-Catenin. delta-Catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.
Molecular Weight 160 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2) (AA 85-194) antibody Western blot analysis of delta-Catenin on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of delta-Catenin.
Product cited in: Lu, Paredes, Medina et al.: "delta-catenin, an adhesive junction-associated protein which promotes cell scattering." in: The Journal of cell biology, Vol. 144, Issue 3, pp. 519-32, 1999 (PubMed).

Ho, Zhou, Medina et al.: "delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development." in: The Journal of comparative neurology, Vol. 420, Issue 2, pp. 261-76, 2000 (PubMed).

Izawa, Nishizawa, Ohtakara et al.: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, 2002 (PubMed).

Laura, Witt, Held et al.: "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12906-14, 2002 (PubMed).

General Zhou, Liyanage, Medina et al.: "Presenilin 1 interaction in the brain with a novel member of the Armadillo family." in: Neuroreport, Vol. 8, Issue 8, pp. 2085-90, 1997 (PubMed).

Hosts (8), (6), (2)
Reactivities (13), (6), (5), (4), (1)
Applications (16), (5), (4), (3), (2), (2), (1), (1)
Epitopes (4), (3), (2), (1), (1), (1)
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