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PDCD6IP antibody (Programmed Cell Death 6 Interacting Protein) (AA 375-580)

Details for Product anti-PDCD6IP Antibody No. ABIN968616, Supplier: Log in to see
Antigen
  • AIP1
  • ALIX
  • Aip1
  • Alix
  • CG12876
  • DAIP1
  • Dmel\\CG12876
  • GB11744
  • DDBDRAFT_0167145
  • DDBDRAFT_0185177
  • DDB_0167145
  • DDB_0185177
  • zgc:63638
  • wu:fb70d03
  • wu:fy65h02
  • PDCD6IP
  • aip1
  • alix
  • hp95
  • drip4
  • 2310011D08Rik
  • AI480459
  • mKIAA1743
  • DRIP4
  • HP95
  • AI480591
  • AW544830
  • C76364
  • Eig2
  • mKIAA1375
  • RGD1561176
  • NORI-1
Alternatives
anti-Mouse (Murine) PDCD6IP antibody for Enzyme Immunoassay
Epitope
AA 375-580
17
13
11
9
6
4
3
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
82
29
27
4
2
Host
Mouse
51
24
10
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PDCD6IP antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
55
38
26
11
11
10
3
3
3
3
2
1
1
Supplier
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Immunogen Mouse AIP1 aa. 375-580
Clone 49-AIP1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name AIP1 (PDCD6IP Antibody Abstract)
Background Apoptosis is a selective process of genetically programmed cell death which occurs during normal cell differentiation and development of multicellular organisms. In vertebrates, T cell and neuronal development are probably the best characterized systems for the study of apoptosis. ALG-2 and ALG-3 (apoptosis-linked genes 2 and 3) were identified as low molecular weight Ca2+-binding proteins essential for apoptosis through the activation of the Fas receptor in T cells. ALG-2 Interacting Protein 1 (AIP1/Alix) is a ubiquitous protein that associates with ALG-2 in the cytosol in a Ca2+ dependent manner. AIP1 is homologous to the yeast protein, BRO1, which has been implicated in Pkc1p- AP kinase signaling. A truncated form of AIP1 protects against serum starvation-, etoposide-, and staurosporine-induced cell death. In addition, the C-terminal proline rich region of AIP1 facilitates interaction with SH3 domain-containing protein expressed in tumorigenic astrocytes (SETA) and this interaction may be important for mediating DNA damage-dependent apoptosis in astrocytes. Thus, AIP1 interacts with ALG-2 or SETA, or both, during activation of cell death pathways in a variety of cell types.
Synonyms: ALG-2 Interacting Protein 1, Alix
Molecular Weight 105 kDa
Research Area Neurology
Pathways p53 Signaling, EGFR Signaling Pathway
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-PDCD6IP antibody (Programmed Cell Death 6 Interacting Protein) (AA 375-580) (ABIN968616) Western blot analysis of AIP1 on a rat testis lysate. Lane 1: 1:250, lane 2: 1:500, l...
Product cited in: Chen, Borinstein, Gillis et al.: "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 19275-81, 2000 (PubMed).

Vito, Pellegrini, Guiet et al.: "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction." in: The Journal of biological chemistry, Vol. 274, Issue 3, pp. 1533-40, 1999 (PubMed).