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B Lymphoid Tyrosine Kinase (BLK) antibody

Details for Product No. ABIN968983
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Antigen
Synonyms bltk, si:dkey-33i22.2, zgc:136231, MODY11
Reactivity
Human
(94), (39), (26), (1), (1), (1)
Host
Mouse
(60), (40), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(76), (59), (45), (16), (10), (7), (6), (5), (5), (4), (4), (1)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN968983
363.00 $
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Immunogen Purified recombinant fragment of human BLK expressed in E. coli.
Clone 1-00E-06
Isotype IgG1
Purification Ascites
Alternative Name BLK
Background Synonyms:
MODY11, MGC10442, BLK
Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development. Activation of B cells by various ligands is accompanied by activation of Blk. It has been suggested that Blk is involved in the control of B cell differentiation and proliferation. Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis. Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.
Molecular Weight 58 kDa
Gene ID 640
Research Area Apoptosis/Necrosis
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-B Lymphoid Tyrosine Kinase (BLK) antibody Figure 3: Flow cytometric analysis of HL-60 cells using BLK mouse mAb (green) and negative control (purple) .
anti-B Lymphoid Tyrosine Kinase (BLK) antibody (2) Figure 2: Immunofluorescence analysis of Hela cells using BLK mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-B Lymphoid Tyrosine Kinase (BLK) antibody (3) Figure 1: Western blot analysis using BLK mAb against HEK293 (1) and BLK (AA: 2-200) -hIgGFc transfected HEK293 (2) cell lysate.
Product cited in: Yang, Ng, Zhao et al.: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Borowiec, Liew, Thompson et al.: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Validation Images
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