Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN968993

Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms cbl, Cbl-2, c-Cbl, 4732447J05Rik, C-CBL, CBL2, FRA11B, NSLL, RNF55, RGD1561386, c-cbl-like
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 2 references available
Catalog no. ABIN968993
Quantity 100 µL
Price
396.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human C-CBL expressed in E. coli.
Clone 3B12
Isotype IgG1
Purification Ascites
Alternative Name C-CBL
Background Synonyms:
CBL, CBL2, NSLL, C-CBL, RNF55
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Molecular Weight 120 kDa
Gene ID 867
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Sproul, Xu, Wilhelm et al.: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).

Sanada, Suzuki, Shih et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).

Alternatives for antigen "Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL)", type "Antibodies"
Hosts (179), (20), (10)
Reactivities (202), (133), (131), (62), (50), (50), (24)
Applications (135), (81), (60), (49), (39), (37), (20), (16), (9), (3), (3), (3), (1), (1)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (33), (28), (19), (18), (18), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon