Add to Basket Bulk discount
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) antibody

Antigen

Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL)
Synonyms cbl, Cbl-2, c-Cbl, 4732447J05Rik, CBL2, C-CBL, RNF55
Clonality Monoclonal (3B12)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Western Blotting (WB)
2 references available
Catalog no. ABIN968993
Quantity 0.1ml
Price 396.00 $   Plus shipping costs $45.00
Bulk discount
Shipping to
Availability Will be delivered in 3 to 4 Business Days

Additional Information
Application Details Publications Alternatives back to top

Alternative name C-CBL
Gene ID 867
Immunogen Purified recombinant fragment of human C-CBL expressed in E. Coli.
Format Liquid
Isotype IgG1
Clone 3B12
Description The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Synonyms: CBL, CBL2, NSLL, C-CBL, RNF55
Molecular Weight 120kDa

Application Details
Publications Alternatives back to top

Application Notes Western Blotting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascites
Buffer Ascitic fluid containing 0.03% sodium azide.
Preservative 0.03% sodium azide
Storage Store at 4℃, for long term storage, store at -20℃.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Sproul, Xu, Wilhelm et al.: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).

Sanada, Suzuki, Shih et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL)", type "Antibodies"
Hosts Rabbit (114), Mouse (8), Goat (7)
Reactivities Human (126), Rat (Rattus) (83), Mouse (Murine) (79), Cow (Bovine) (25), Dog (Canine) (25), Pig (Porcine) (25), Horse (Equine) (23), Chicken (5)
Applications Western Blotting (WB) (69), Immunofluorescence (IF) (61), ELISA (39), Immunohistochemistry (IHC) (27), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19), Immunocytochemistry (ICC) (11), Immunoprecipitation (IP) (11), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Flow Cytometry (FACS) (4), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Dot Blot (Dot) (1), Fluorescence Microscopy (FM) (1), Immunoassay (IA) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), PE,Cy5.5 (5), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes C-Term (14), pTyr700 (9), pTyr731 (7), pTyr774 (7), pTyr674 (6), pTyr731,C-Term (3), Internal Region (2), Tyr700 (2), AA 878-906 (1), N-Term (1), Tyr770 (1), pSer45,pThr41 (1), pSer669 (1), pTyr770 (1)