Fibulin 5 antibody (AA 242-448)

Catalog No. ABIN969131

The Mouse Monoclonal anti-Fibulin 5 antibody has been validated for IHC and ELISA. It is suitable to detect Fibulin 5 in samples from Human. There are 3+ publications available.

Quick Overview for Fibulin 5 antibody (AA 242-448) (ABIN969131)

Target: Fibulin 5 (FBLN5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibulin 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 1G6A4

Product Details anti-Fibulin 5 Antibody

Binding Specificity: AA 242-448

Purpose: FBLN5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Fibulin 5 antibody (ABIN969131)

Wang, LeMaire, Chen, Carter, Shen, Gan, Bartsch, Wilks, Utama, Ou, Thompson, Coselli, Wang: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, (2005) (PubMed).

Stone, Braun, Russell, Kuehn, Lotery, Moore, Eastman, Casavant, Sheffield: "Missense variations in the fibulin 5 gene and age-related macular degeneration." in: The New England journal of medicine, Vol. 351, Issue 4, pp. 346-53, (2004) (PubMed).

Markova, Zou, Ringpfeil, Sasaki, Kostka, Timpl, Uitto, Chu: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, (2003) (PubMed).

Target Details for Fibulin 5

Target: Fibulin 5 (FBLN5)

Alternative Name: FBLN5

Background: FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

UniProt: Q9UBX5

Pathways: SARS-CoV-2 Protein Interactome