FES antibody (Feline Sarcoma Oncogene)

Details for Product anti-FES Antibody No. ABIN969135, Supplier: Log in to see
Antigen
  • FES
  • c-fps
  • FPS
  • AI586313
  • BB137047
  • c-fes
  • RGD1564385
  • feline sarcoma oncogene
  • FES
  • fes
  • Fes
Alternatives
anti-Human FES antibody for ELISA
Reactivity
Human
93
32
20
4
4
4
4
4
3
3
2
1
1
1
Host
Mouse
53
40
2
Clonality (Clone)
Monoclonal ()
Conjugate
This FES antibody is un-conjugated
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
85
53
31
15
5
4
3
3
3
2
1
Options
Supplier
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Immunogen Purified recombinant fragment of FES expressed in E. Coli.
Clone 5A11G5
Isotype IgG1
Purification Ascites
Alternative Name FES (FES Antibody Abstract)
Background FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Gene ID 2242
HGNC 2242
Research Area Cancer, Tyrosine Kinases
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Western Blotting (WB) image for anti-FES antibody (Feline Sarcoma Oncogene) (ABIN969135) Figure 1: Western blot analysis using FES mouse mAb against truncated FES recombinant...
Product cited in: Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, 2006 (PubMed).

Durfee, Rivard: "Design and simulation of a pneumatic, stored-energy, hybrid orthosis for gait restoration." in: Journal of biomechanical engineering, Vol. 127, Issue 6, pp. 1014-9, 2006 (PubMed).

Vitenzon, Mironov, Petrushanskaya: "Functional electrostimulation of muscles as a method for restoring motor functions." in: Neuroscience and behavioral physiology, Vol. 35, Issue 7, pp. 709-14, 2006 (PubMed).