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Insulin-Like Growth Factor 2 MRNA Binding Protein 3 (IGF2BP3) antibody

Details for Product No. ABIN969208
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Antigen
Synonyms
imp3, koc1, vera, imp-3, vg1rbp, vickz3, CT98, IMP-3, IMP3, KOC1, VICKZ3, 2610101N11Rik, AA522010, AL022933, AU045931, Koc13, Neilsen, mimp3, Ab2-255, RGD1306512, dvr1rbp, wu:fb79c12, wu:fe06h09, zVg1 ... show more
imp3, koc1, vera, imp-3, vg1rbp, vickz3, CT98, IMP-3, IMP3, KOC1, VICKZ3, 2610101N11Rik, AA522010, AL022933, AU045931, Koc13, Neilsen, mimp3, Ab2-255, RGD1306512, dvr1rbp, wu:fb79c12, wu:fe06h09, zVg1RBP show less
Reactivity
Human
(39), (19), (17), (13), (1)
Host
Mouse
(32), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(27), (10), (10), (9), (9), (3)
Pubmed 1 reference available
Quantity 100 µL
Options
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Catalog No. ABIN969208
363.00 $
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Immunogen Purified recombinant fragment of human IGF2BP3 expressed in E. coli.
Clone 8F11
Isotype IgG1
Purification Ascites
Alternative Name IGF2BP3
Background Synonyms:
CT98, IMP3, KOC1, IMP-3, VICKZ3, DKFZp686F1078, IGF2BP3
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and mηbolism. Tissue specificity: Expressed in fηl liver, fηl lung, fηl kidney, fηl thymus, fηl placenta, fηl follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fηl development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.
Molecular Weight 69 kDa
Gene ID 10643
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Insulin-Like Growth Factor 2 MRNA Binding Protein 3 (IGF2BP3) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and colon tumour tissues (right) using IGC2BP3 mouse mAb with DAB staining.
anti-Insulin-Like Growth Factor 2 MRNA Binding Protein 3 (IGF2BP3) antibody (2) Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.
Product cited in: Sitnikova, Mendese, Liu et al.: "IMP3 predicts aggressive superficial urothelial carcinoma of the bladder." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 6, pp. 1701-6, 2008 (PubMed).

Validation Images
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