IL2-Inducible T-Cell Kinase (ITK) antibody

Details for Product No. ABIN969222
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Antigen
Synonyms Emt, Tcsk, Tsk, EMT, LPFS1, LYK, PSCTK2
Reactivity
Human
(80), (25), (17), (13), (12), (12), (12)
Host
Mouse
(46), (23), (14)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(66), (38), (10), (9), (6), (6), (4), (4), (4), (2), (1)
Pubmed 1 reference available
Quantity 100 μL
Options
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Catalog No. ABIN969222
396.00 $
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  • +1 404 474 4654
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Immunogen Purified recombinant fragment of human ITK expressed in E. coli.
Clone 5G6
Isotype IgG1
Purification Ascites
Alternative Name ITK
Background Synonyms:
EMT, LYK, PSCTK2, MGC126257, MGC126258
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Molecular Weight 72 kDa
Gene ID 3702
Research Area Signaling, Tyrosine Kinases
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-IL2-Inducible T-Cell Kinase (ITK) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-IL2-Inducible T-Cell Kinase (ITK) antibody (2) Figure 4: Flow cytometric analysis of Jurkat cells using ITK mouse mAb (blue) and negative control (red) .
anti-IL2-Inducible T-Cell Kinase (ITK) antibody (3) Figure 3: Immunofluorescence analysis of Jurkat cells using ITK mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye.
anti-IL2-Inducible T-Cell Kinase (ITK) antibody (4) Figure 2: Western blot analysis using ITK mouse mAb against Jurkat cell lysate.
anti-IL2-Inducible T-Cell Kinase (ITK) antibody (5) Figure 1: Western blot analysis using ITK mAb against human ITK (AA: 2-120) recombinant protein. (Expected MW is 39.7 kDa)
Product cited in: Huck, Feyen, Niehues et al.: "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation." in: The Journal of clinical investigation, Vol. 119, Issue 5, pp. 1350-8, 2009 (PubMed).

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