anti-ITK antibody (IL2-Inducible T-Cell Kinase)

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Antigen
Synonyms Emt, Tcsk, Tsk, EMT, LPFS1, LYK, PSCTK2
Alternatives
Reactivity
Human
(108), (25), (24), (3), (1), (1), (1), (1)
Host
Mouse
(63), (32), (25)
Clonality (Clone)
Monoclonal ()
Conjugate
This ITK antibody is un-conjugated
(7), (6), (6), (6), (6), (5), (1)
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
(98), (73), (8), (6), (6), (4), (4), (4), (3), (2), (1)
Pubmed 2 references available
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Quantity 100 μL
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Immunogen Purified recombinant fragment of human ITK expressed in E. coli.
Clone 5G6
Isotype IgG1
Purification Ascites
Alternative Name ITK (ITK Antibody Abstract)
Background This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Molecular Weight 72 kDa
Gene ID 3702
HGNC 3702
Research Area Signaling, Tyrosine Kinases
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-ITK antibody (IL2-Inducible T-Cell Kinase) (ABIN969222) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Flow Cytometry (FACS) image for anti-ITK antibody (IL2-Inducible T-Cell Kinase) (ABIN969222) Figure 2: Flow cytometric analysis of Jurkat cells using ITK mouse mAb (blue) and neg...
Immunocytochemistry (ICC) image for anti-ITK antibody (IL2-Inducible T-Cell Kinase) (ABIN969222) Figure 3: Immunofluorescence analysis of Jurkat cells using ITK mouse mAb (green) . B...
Western Blotting (WB) image for anti-ITK antibody (IL2-Inducible T-Cell Kinase) (ABIN969222) Figure 4: Western blot analysis using ITK mouse mAb against Jurkat cell lysate.
Western Blotting (WB) image for anti-ITK antibody (IL2-Inducible T-Cell Kinase) (ABIN969222) Figure 5: Western blot analysis using ITK mAb against human ITK (AA: 2-120) recombina...
Product cited in: Kogina, Shoda, Yamaguchi et al.: "Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4(+) T cells." in: Molecules and cells, Vol. 28, Issue 2, pp. 125-30, 2009 (PubMed).

Huck, Feyen, Niehues et al.: "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation." in: The Journal of clinical investigation, Vol. 119, Issue 5, pp. 1350-8, 2009 (PubMed).

Catalog No. ABIN969222
$430.10
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