MBP antibody

Catalog No. ABIN969279

This anti-MBP antibody is a Mouse Monoclonal antibody detecting MBP in IHC, ELISA, ICC and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for MBP antibody (ABIN969279)

Target: MBP (Myelin Basic Protein (MBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MBP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 2H9

Product Details anti-MBP Antibody

Purpose: MBP Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MBP expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MBP antibody (ABIN969279)

Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, (2009) (PubMed).

Hoos, Ahmed, Smith, Van Nostrand: "Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro." in: Biochemistry, Vol. 48, Issue 22, pp. 4720-7, (2009) (PubMed).

Target Details for MBP

Target: MBP (Myelin Basic Protein (MBP))

Alternative Name: Myelin basic protein

Background: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Molecular Weight: 33 kDa

Gene ID: 4155

UniProt: P02686