MYL2 antibody

Catalog No. ABIN969302

The Mouse Monoclonal anti-MYL2 antibody has been validated for WB and ELISA. It is suitable to detect MYL2 in samples from Human. There are 2+ publications available.

Quick Overview for MYL2 antibody (ABIN969302)

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7C9

Product Details anti-MYL2 Antibody

Purpose: MYL2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MYL2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MYL2 antibody (ABIN969302)

Sachdev, Raychowdhury, Sarkar: "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 14, Issue 5, pp. 339-50, (2004) (PubMed).

Ueda, Murata-Hori, Tatsuka, Hosoya: "Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells." in: Oncogene, Vol. 21, Issue 38, pp. 5852-60, (2002) (PubMed).

Target Details for MYL2

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Alternative Name: MYL2

Background: MYL2(myosin, light chain 2, regulatory, cardiac, slow), also known as MLC-2, MLC2v. Entrez protein NP_000423. MYL2 associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. It is an hexamer of two heavy chains and four light chains that is predominantly expressed in adult cardiac ventricle muscle. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Molecular Weight: 19 kDa

Gene ID: 4633

UniProt: P10916

Pathways: Myometrial Relaxation and Contraction