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Progesterone Receptor antibody (PGR) (AA 730-871)

Details for Product anti-PGR Antibody No. ABIN969352, Supplier: Log in to see
Antigen
  • PR
  • XPR-1
  • pgr
  • xpr-2
  • PGR
  • pg
  • pr
  • gb:dq017620
  • NR3C3
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • PR-A
  • PR-B
  • LOC443444
Alternatives
anti-Human Progesterone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 730-871
73
53
42
36
32
27
19
18
17
17
16
15
13
9
8
8
8
7
7
7
6
5
5
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
573
70
68
15
6
5
4
3
2
2
1
Host
Mouse
334
251
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Progesterone Receptor antibody is un-conjugated
16
15
13
8
8
8
3
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
407
155
153
144
105
49
46
26
24
9
7
3
3
3
2
2
1
1
1
1
1
Supplier
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Immunogen Purified recombinant fragment of PGR (AA 730-871) expressed in E. coli.
Clone 8A11H1
Isotype IgG1
Purification Ascites
Alternative Name PGR (PGR Antibody Abstract)
Background PGR: progesterone receptor. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.
Gene ID 5241
HGNC 5241
Pathways Nuclear Receptor Transcription Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-Progesterone Receptor antibody (PGR) (AA 730-871) (ABIN969352) Figure 1: Western blot analysis using PGR mouse mAb against truncated MBP-PGR recombi...
Product cited in: Yin, Lin, Cheng et al.: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, 2007 (PubMed).

LEplattenier, Lai, van den Ham et al.: "Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation." in: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 21, Issue 4, pp. 776-82, 2007 (PubMed).

Saito, Ito, Nagase et al.: "Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma." in: Cancer science, Vol. 97, Issue 12, pp. 1308-14, 2006 (PubMed).

Buser, Gass-Handel, Wyszomierski et al.: "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 1, pp. 106-25, 2006 (PubMed).

Tung, Abdel-Hafiz, Shen et al.: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, 2006 (PubMed).