Progesterone Receptor (PGR) (AA 730-871) antibody

Details for Product No. ABIN969352
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Antigen
Synonyms PR, XPR-1, pgr, xpr-2, PGR, pg, pr, gb:dq017620, NR3C3, 9930019P03Rik, BB114106, ENSMUSG00000074510, PR-A, PR-B, LOC443444
Epitope
AA 730-871
(49), (39), (25), (21), (15), (14), (11), (9), (9), (8), (8), (7), (7), (6), (5), (5), (5), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(388), (74), (72), (14), (12), (7), (6), (3), (2), (2), (1), (1), (1)
Host
Mouse
(252), (160), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3)
Application
ELISA, Western Blotting (WB)
(269), (147), (99), (95), (62), (53), (52), (39), (30), (6), (2), (1), (1)
Pubmed 4 references available
Quantity 100 μL
Options
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Catalog No. ABIN969352
363.00 $
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Immunogen Purified recombinant fragment of PGR (AA 730-871) expressed in E. coli.
Clone 8A11H1
Isotype IgG1
Purification Ascites
Alternative Name PGR
Background Synonyms:
PR, NR3C3, PGR
PGR: progesterone receptor. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 AA found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.
Gene ID 5241
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Progesterone Receptor (PGR) (AA 730-871) antibody Figure 1: Western blot analysis using PGR mouse mAb against truncated MBP-PGR recombinant protein (1) and truncated Trx-PGR (aa730-871) recombinant protein (2) .
Product cited in: Tung, Abdel-Hafiz, Shen et al.: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, 2006 (PubMed).

Saito, Ito, Nagase et al.: "Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma." in: Cancer science, Vol. 97, Issue 12, pp. 1308-14, 2006 (PubMed).

LEplattenier, Lai, van den Ham et al.: "Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation." in: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 21, Issue 4, pp. 776-82, 2007 (PubMed).

Yin, Lin, Cheng et al.: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, 2007 (PubMed).

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