Progesterone Receptor antibody (AA 1-110)

Catalog No. ABIN562204

This Mouse Monoclonal antibody specifically detects Progesterone Receptor in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for Progesterone Receptor antibody (AA 1-110) (ABIN562204)

Target: Progesterone Receptor (PGR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5D10

Product Details anti-Progesterone Receptor Antibody

Binding Specificity: AA 1-110

Purpose: Mouse monoclonal antibody raised against a partial recombinant PGR. This PGR gene uses two distinct promoters and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B. Our immunogen corresponds to the specific region of isoform B, thus this antibody is a PGR isofrom B specific antibody.

Sequence: MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL

Cross-Reactivity: Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: PGR (NP_000917, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Progesterone Receptor antibody (ABIN562204)

Liu, Chang, Kuo, Hwa, Lin, Huang, Chen, Chang, Hsieh: "Major Functional Transcriptome of an Inferred Center Regulator of an ER(-) Breast Cancer Model System." in: Cancer informatics, Vol. 11, pp. 87-111, (2012) (PubMed).

Liu, Chang, Kuo, Hwa, Shyu, Chang, Hsieh: "In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer Population." in: Cancer informatics, Vol. 11, pp. 113-37, (2012) (PubMed).

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: PGR

Background: Full Gene Name: progesterone receptor
Synonyms: NR3C3,PR

Gene ID: 5241

NCBI Accession: NM_000926

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration