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Details for Product No. ABIN969366

Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody

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Antigen
Synonyms HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, dna-pkcs, dnapk, dnpk1, hyrc, hyrc1, prkdc-A, xrcc7, AI326420, AU019811, DNAPDcs, DOXNPH, dxnph, p460, scid, slip, DNA-PKCS, PRKDC
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN969366
Quantity 100 µL
Price
396.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human PRKDC expressed in E. coli.
Clone 3H6
Isotype IgG1
Purification Ascites
Alternative Name PRKDC
Background Synonyms:
HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, PRkDaC
The PRkDaC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRkDaC must be bound to DNA to express its catalytic properties.
Molecular Weight 46.9 kDa
Gene ID 5591
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Huston, Lynch, Mohamed et al.: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).

Durkin, Guo, Fryrear et al.: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Alternatives for antigen "Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC)", type "Antibodies"
Hosts (175), (61)
Reactivities (230), (109), (46), (41), (30), (12), (12), (6), (4), (1), (1)
Applications (125), (86), (70), (62), (55), (47), (17), (14), (14), (3), (2), (2), (1), (1), (1)
Conjugates (10), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7)
Epitopes (38), (14), (13), (13), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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