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Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody

Details for Product No. ABIN969366, Supplier: Login to see
Antigen
  • PRKDC
  • AI326420
  • AU019811
  • DNA-PKcs
  • DNAPDcs
  • DNAPK
  • DNPK1
  • DOXNPH
  • HYRC1
  • XRCC7
  • dxnph
  • p460
  • scid
  • slip
  • HYRC
  • p350
  • dna-pkcs
  • dnapk
  • dnpk1
  • hyrc
  • hyrc1
  • prkdc-A
  • xrcc7
  • DNA-PKCS
Alternatives
anti-Human Protein Kinase, DNA-Activated, Catalytic Polypeptide antibody for Electrophoretic Mobility-Shift Assay
Reactivity
Human
372
125
40
5
4
4
3
3
2
1
1
1
Host
Mouse
304
73
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
18
17
16
9
8
8
8
7
7
7
7
7
7
7
7
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
170
129
98
80
74
74
50
20
16
8
8
6
3
2
2
1
1
1
Supplier
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Immunogen Purified recombinant fragment of human PRKDC expressed in E. coli.
Clone 3H6
Isotype IgG1
Purification Ascites
Alternative Name PRKDC (PRKDC Antibody Abstract)
Background The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.
Molecular Weight 46.9 kDa
Gene ID 5591
HGNC 5591
Pathways DNA Damage Repair
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN969366) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN969366) Figure 2: Immunofluorescence analysis of Hela cells using PRKDC mouse mAb (green) . R...
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN969366) Figure 3: Immunohistochemical analysis of paraffin-embedded breast cancer (left) and ...
Immunohistochemistry (IHC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN969366) Figure 4: Immunohistochemical analysis of paraffin-embedded lung cancer (left) and br...
Western Blotting (WB) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody (ABIN969366) Figure 5: Western blot analysis using PRKDC mAb against HEK293 (1) and PRKDC (AA: 263...
Product cited in: Durkin, Guo, Fryrear et al.: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, 2008 (PubMed).

Huston, Lynch, Mohamed et al.: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, 2008 (PubMed).