ARHGAP8 antibody (Middle Region)

Catalog No. ABIN970136

The Rabbit Polyclonal anti-ARHGAP8 antibody is suitable to detect ARHGAP8 in samples from Horse, Human, Cow, Dog, Guinea Pig, Mouse and Rat. It has been validated for WB.

Quick Overview for ARHGAP8 antibody (Middle Region) (ABIN970136)

Target: ARHGAP8 (rho GTPase Activating Protein 8 (ARHGAP8))

Reactivity: Horse, Human, Cow, Dog, Guinea Pig, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARHGAP8 Antibody

Binding Specificity: Middle Region

Sequence: PRPPLPTQQF GVSLQYLKDK NQGELIPPVL RFTVTYLREK GLRTEGLFRR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARHGAP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ARHGAP8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 433 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARHGAP8

Target: ARHGAP8 (rho GTPase Activating Protein 8 (ARHGAP8))

Alternative Name: ARHGAP8

Background: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Alias Symbols: BPGAP1, FLJ20185, PP610
Protein Interaction Partner: UBC, SH3GL1, RHOA, CDC42, BNIP2, ARHGAP1, ARHGAP8, CTTN, RAC1,
Protein Size: 433

Molecular Weight: 50 kDa

Gene ID: 23779

NCBI Accession: NM_181335, NP_851852

UniProt: Q86XV6