ARHGAP8 antibody (Middle Region)

Catalog No. ABIN2790172

Product Details anti-ARHGAP8 Antibody

Target: ARHGAP8 (rho GTPase Activating Protein 8 (ARHGAP8))

Binding Specificity: Middle Region

Reactivity: Horse, Human, Cow, Dog, Guinea Pig, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PRPPLPTQQF GVSLQYLKDK NQGELIPPVL RFTVTYLREK GLRTEGLFRR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARHGAP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ARHGAP8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 433 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARHGAP8

Target: ARHGAP8 (rho GTPase Activating Protein 8 (ARHGAP8))

Alternative Name: ARHGAP8 (ARHGAP8 Products)

Synonyms: BPGAP1 antibody, PP610 antibody, 3110043J09Rik antibody, AU043908 antibody, Arhgap8 antibody, C030017C09Rik antibody, C78947 antibody, Protor-1 antibody, Protor1 antibody, Rho GTPase activating protein 8 antibody, proline rich 5 (renal) antibody, proline rich 5 antibody, ARHGAP8 antibody, Arhgap8 antibody, arhgap8 antibody, Prr5 antibody

Background: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Alias Symbols: BPGAP1, FLJ20185, PP610
Protein Interaction Partner: UBC, SH3GL1, RHOA, CDC42, BNIP2, ARHGAP1, ARHGAP8, CTTN, RAC1,
Protein Size: 433

Molecular Weight: 50 kDa

Gene ID: 23779

NCBI Accession: NM_181335, NP_851852

UniProt: Q86XV6