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|Application / Reactivity||Mouse (Murine)||Human|
|Blocking Reagent (BR)||2 Antibodies|
|ELISA||19 Antibodies||60 Antibodies|
|Enzyme Immunoassay (EIA)||5 Antibodies||5 Antibodies|
|Flow Cytometry (FACS)||4 Antibodies||21 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies||10 Antibodies|
|Immunofluorescence (IF)||2 Antibodies||6 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies|
|Western Blotting (WB)||46 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TNFRSF25 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF25 AntibodyTarget Details TNFRSF25 Application Details Handling References for anti-TNFRSF25 Antibody (ABIN499758) Images
|Immunogen||Synthetic peptide corresponding to amino acids in extracellular domain (ED) of Human DR3 precusor.|
Target Details TNFRSF25Product Details anti-TNFRSF25 Antibody Application Details Handling References for anti-TNFRSF25 Antibody (ABIN499758) Images back to top
|Alternative Name||TNFRSF25 / DR3 / TRAMP (TNFRSF25 Antibody Abstract)|
|Background||Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.Synonyms: AIR, APO3, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR3, Death receptor 3, LARD, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, TNFRSF12, Tumor necrosis factor receptor superfamily member 25, WSL, WSL1|
Application DetailsProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Handling References for anti-TNFRSF25 Antibody (ABIN499758) Images back to top
ELISA. Western Blot: 1/500 to 1/1000.59 kDa band should be detected. Immuocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details References for anti-TNFRSF25 Antibody (ABIN499758) Images back to top
|Buffer||PBS containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-TNFRSF25 Antibody (ABIN499758)Product Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details Handling Images back to top
Marsters, Sheridan, Donahue et al.: "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B." in: Current biology : CB, Vol. 6, Issue 12, pp. 1669-76, 1997 (PubMed).
Kitson, Raven, Jiang et al.: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).
Chinnaiyan, ORourke, Yu et al.: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).
ImagesProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details Handling References for anti-TNFRSF25 Antibody (ABIN499758) back to top