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Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B ELISA Kits)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B ELISA Kits)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B ELISA Kits)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
Study corroborated results from a previous report that described interactions between ADORA2A and CYP1A2 (show CYP1A2 ELISA Kits) polymorphisms and coffee consumption in Parkinson's disease.
However, the contribution of the A2AR to the control of impulsive reward seeking remains unknown. Using mice that were exposed to differential reward of low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and the 5-choice serial reaction time task (5 (show KCNK15 ELISA Kits)-CSRTT), we demonstrate that deficits of A2AR function promote impulsive responses.
Western blot analysis indicates that the A2A receptor is more abundant in the hippocampus of medial temporal lobe epilepsy patients compared to control individuals. Immunoreactivity against the A2A receptor predominates in astrocytes staining positively for the glial fibrillary acidic protein (show GFAP ELISA Kits).
Results suggest that the combination of the ADORA2A rs2298383TT and MTHFR (show MTHFR ELISA Kits) 1298AC-677CT genotypes might lead to a low risk of nodule formation in patients treated with methotrexate.
results unveil intracellular signaling pathways targeted by the A2AR, some of which might be key in modulating neutrophil functions.
Calcium modulates calmodulin-ACTN1 (show ACTN1 ELISA Kits) interaction with and agonist-dependent internalization of the adenosine A2A receptor.
A2A AR activation on BBB (show ALMS1 ELISA Kits) endothelial cells offers a therapeutic window that can be fine-tuned for drug delivery to the brain and has potential as a CNS drug-delivery technology.
Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf (show RAF1 ELISA Kits)-ERK (show EPHB2 ELISA Kits) pathway.
A1R (show ADORA1 ELISA Kits) signaling enhances A2AR-mediated neurodegeneration [review]
ADORA2A rs2298383 and high cumulative dose of systemic methotrexate (MTX (show MTX1 ELISA Kits)) administration were significantly associated with MTX (show MTX1 ELISA Kits)-related leukoencephalopathy
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 (show FPR2 ELISA Kits) were mediated successively by the PGD2 (show PTGDS ELISA Kits)-DP1 (show REEP5 ELISA Kits) receptor, adenosine-A2A receptor, and GABA-GABAA (show GABRg1 ELISA Kits) receptor systems downstream of the FPR2 (show FPR2 ELISA Kits).
Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice.
Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits) signalling and cardiac injury without influencing cardiac depression in endotoxemia.
The three receptor sets considered (mAChR (show CHRM3 ELISA Kits), AR and TrkB (show NTRK2 ELISA Kits) receptors) intervene in modulating the conditions of the competition between nerve endings.
High A2aR expression is associated with Melanoma Metastasis.
These novel findings indicate that adenosine suppresses REM (show REM1 ELISA Kits) sleep via A2AR in the OB of rodents.
The findings suggest that disruption of the protective A2AR amplifies inflammation to accelerate glomerular damage and endogenous macrophage A2ARs are essential to protect from progressive kidney fibrosis.
this study has identified a unique role for A2aRs in regulating CD4 (show CD4 ELISA Kits) T cell differentiation during vaccination.
these observations point to a previously unappreciated role of GS protein-coupled A2aR in regulating humoral immunity, which may be pharmacologically targeted during vaccination or pathological states in which GC-derived autoantibodies contribute to the pathology.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 ELISA Kits) production by LPS (show IRF6 ELISA Kits)-stimulated equine neutrophils in a cAMP-dependent manner.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, A2a adenosine receptor
, adenosine receptor A2a-like
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor