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These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC (show TRPV6 ELISA Kits) synthesis.
crlr (show CALCRL ELISA Kits) plays a nonredundant role in arterial differentiation, representing a novel element of the sonic hedgehog (show SHH ELISA Kits)-vegf (show VEGFA ELISA Kits)-notch (show NOTCH1 ELISA Kits) signaling cascade that controls arterial/venous fate
structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy
Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (show CALCA ELISA Kits) for CTR ECD (show SHFM1 ELISA Kits); the same appears to apply for enhanced affinity of amylin (show IAPP ELISA Kits) for RAMP2 (show RAMP2 ELISA Kits)-CTR ECD (show SHFM1 ELISA Kits). [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD (show SHFM1 ELISA Kits) = extracellular domain; RAMP2 (show RAMP2 ELISA Kits) = receptor (calcitonin) activity modifying protein 2 (show RAMP2 ELISA Kits)].
Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India.
Calcitonin (show CALCA ELISA Kits) and Amylin (show IAPP ELISA Kits) Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis.
Data indicate a potential association between 3'UTR (show UTS2R ELISA Kits)+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease.
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin (show CALCA ELISA Kits), reveals ligand bias.
High calcitonin receptor is associated with prostate cancer.
the expression of CTR is associated with the early cellular events involved in atherosclerotic plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC (show MSC ELISA Kits) niche.
data suggest that Clr-b (show CLEC2D ELISA Kits) modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta (show IL1B ELISA Kits)
Together, these data indicate that signaling through RAMP1 (show RAMP1 ELISA Kits) and CLR plays a role in mediating asthma pathology
The relevance of the OPG (show TNFSF11 ELISA Kits)/RANK/RANKL (show TNFSF11 ELISA Kits) system in the particle-induced osteolysis process, was investigated.
Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner
Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration.
The perinatal expression of CTR within the ENS suggests that the calcitonin (show CALCA ELISA Kits)/CTR system may have a role in the maturation of enteric neurons
CGRP-receptor component protein (show CRCP ELISA Kits) has been found to interact only with calcitonin (show CALCA ELISA Kits)-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide (show CALCA ELISA Kits) signaling.
CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts.
Intracoronary intermedin (show ADM2 ELISA Kits) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (show CALCA ELISA Kits) receptors and beta-adrenoreceptor-mediated nitric oxide release.
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
, calcitonin receptor-like